Illumina® Genotyping Panels

The flexibility of the Illumina® platform allows high density genome wide genetic association studies as well as customized focused genotyping to investigate specific areas of the genome or disease related pathways.

Infinium Standard Content Arrays

Human-1- Whole–Genome BeadChip: 
Exon centric content with over 100,000 SNPs.  Of these SNPs, approximately 25,000 are in transcripts and about 73,000 are within 10 kb of coding sequences.

HumanHap Whole–Genome 240S:
This array contains an additional 240,000 tag SNPs derived from Phase I and II HapMap data.

HumanMap Whole–Genome 300-Duo BeadChip:
This two-sample array contains over 317,000 tag SNPs derived from Phase I HapMap data.  The BeadChip contains a high density of tag SNPs in genomic regions that are within 10 kb of a gene or evolutionarily conserved regions.  There are about 7,300 non-synonymous SNPs and a high density of SNPs across the Major Histocompatibility Complex (MHC).

Human CNV 370-Duo:
This BeadChip contains the content available on the HumanHap 300-Duo plus an additional ~55,000 markers specifically designed to target nearly 11,000 copy number variant regions of the genome.  Included are probes for SNP and non-SNP sites. 

HumanMap Whole–Genome 550 BeadChip:
This array contains over 550,000 SNP loci derived from Phase I and II HapMap data.  The high density tag SNP content provides the equivalent power of over one million randomly selected SNP markers and is useful for studies across multiple populations.

Human Whole–Genome 650Y BeadChip:
This array contains all the content of the HumanMap Whole-Genome 550 BeadChip plus additional tag SNP content for the Yoruba population.

Human Whole–Genome 1 M BeadChip:
This array provides an unprecedented level of content with over one million SNPs on a single array  This BeadChip targets genes, tag SNPs, copy number variation and other genomic regions including 160 mitochondrial SNPs.  Approximately 400,000 SNPs are with 10 kb of gene regions representing greater than 99% of RefSeq genes.

HumanNS-12 BeadChip:
This 12-sample BeadChip contains over 13,900 SNPs of which over 11,000 are non-synonymous SNPs (nsSNPs).  This array allows rapid whole-genome screening of nsSNPs or complements whole-genome or candidate-gene association studies.

 

Infinium™ Custom Content Arrays

iSelect Infinium Custom Genotyping:
This 12-sample BeadChip allows you to design a custom panel of up to 60,800 bead types.  This is ideal for investigations of specific genomic areas or disease related pathways.

HumanHap Whole-Genome 300 Duo+ BeadChip:
This product allows two samples to be analyzed simultaneously using > 318,000 SNPs with an additional 60,800 custom SNPs.

HumanMap Whole–Genome 550 Plus BeadChip:
This is the HumanMap Whole-Genome 550 BeadChip with an additional 121,600 custom SNPs.

 

GoldenGate Standard Content Arrays

DNA Test Panel:
This panel contains 360 SNPs and can be used to pre-screen DNA samples for performance before conducting large studies or to assess population stratification in study samples.

Cancer SNP Panel:
This panel is designed to conduct candidate gene-based association studies.  The more than 1,400 SNPs derived from over 400 genes thought to be involved in cancer were selected from the National Cancer Institute’s Cancer Genome Anatomy Project SNP 500 Cancer Database.

MHC Panels:
There are three panels for mapping disease-associated variants in the MHC region that can be used independently or can be combined for more extensive coverage.

  • MHC Mapping Panel: This panel contains 1,293 SNPs evenly spaced across the region (average spacing of 3.8 kb)

  • MHC Exon-Centric Panel: This panel contains 1,228 SNPs within 10 kb of coding sequences (average of 7.7 SNPs per gene in the 160 gene region)

  • MHC Panel Set: This panel is an optimized set of 2,360 SNPs consisting of the Mapping Panel and Exon-Centric Panel for comprehensive coverage of the MHC region.